RAS Chemistry & Material ScienceЖурнал неорганической химии Russian Journal of Inorganic Chemistry

  • ISSN (Print) 0044-457X
  • ISSN (Online) 3034-560X

Preparation of a сloso-Dodecaborate Anion Conjugate with Ethyl Glycinate and Study of Its Biodistribution in a B16f10 Melanoma Model

PII
10.31857/S0044457X24060015-1
DOI
10.31857/S0044457X24060015
Publication type
Article
Status
Published
Authors
Volume/ Edition
Volume 69 / Issue number 6
Pages
803-809
Abstract
A method for the synthesis of amidine-closo-dodecaborate based on glycine ethyl ester in the form of sodium salt solvate of high purity and constant composition was proposed in this work. The structure of the obtained solvate was confirmed by X-ray analysis of single crystal. In addition, total and acute toxicity as well as biodistribution in laboratory mice with B16F10 melanoma were determined for the synthesized conjugate Na[B12H11NH=C(NHCH2COOC2H5)CH3].
Keywords
клозо-додекаборатный анион борилированные амидины бор-нейтронозахватная терапия
Date of publication
15.06.2024
Year of publication
2024
Number of purchasers
0
Views
47

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