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RAS Chemistry & Material ScienceЖурнал неорганической химии Russian Journal of Inorganic Chemistry

  • ISSN (Print) 0044-457X
  • ISSN (Online) 3034-560X

The substituted derivative of closo-dodecaborate anion based on para-iodo-L-phenylalanine is a novel compound for BNCT with CT imaging capability

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PII
10.31857/S0044457X24050088-1
DOI
10.31857/S0044457X24050088
Publication type
Article
Status
Published
Authors
N. T. Kuznetsov
  • Affiliation: Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Volume/ Edition
Volume 69 / Issue number 5
Pages
713-719
Abstract
A substituted derivative of closo-dodecaborate anion [B12H11NH=C(CH3)NHCH2CH-4-I-C6H4(COOCH3)]– containing in its structure elements for vector delivery and diagnostics by beam imaging methods was obtained. The structure of the co-compound was established by multinuclear NMR spectroscopy and ESI-mass spectrometry. For aqueous solutions of the compound Na[B12H11NH=C(CH3)NHCH2CH-4-I-C6H4(COOCH3)], the X-ray density was measured and the distribution of the drug in the organs of laboratory animals was studied by computer tomography.
Keywords
клозо-додекаборатный анион бор-нейтронозахватная терапия рентгеновская компьютерная томография йодсодержащие производные
Date of publication
17.09.2025
Year of publication
2025
Number of purchasers
0
Views
11

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