RAS Chemistry & Material ScienceЖурнал неорганической химии Russian Journal of Inorganic Chemistry

  • ISSN (Print) 0044-457X
  • ISSN (Online) 3034-560X

On the Interaction of Gold(III) Complexes with Human Serum Albumin

PII
10.31857/S0044457X23600639-1
DOI
10.31857/S0044457X23600639
Publication type
Status
Published
Authors
Volume/ Edition
Volume 68 / Issue number 10
Pages
1495-1503
Abstract
The interaction of gold(III) complexes (Au(bipy) , Au(phen) , and Au(dien-H)Cl+) with human serum albumin (HSA) was studied in aqueous solutions (pH 7.4, CNaCl = 0.2 M, CAu = (2–10) × 10–5 M, CHSA < 6 × 10–4 M) at 25°C. In all cases, gold(III) is reduced to gold(I), which forms a complex with HSA. When an excess of HSA is present, the time required for complete transformation of the complexes does not exceed 1 h. In addition, it was shown that the redox reaction of gold(III) complexes with cysteine is much faster than the reaction with methionine.
Keywords
азотсодержащие лиганды комплексообразование тиолы
Date of publication
17.09.2025
Year of publication
2025
Number of purchasers
0
Views
12

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